Experts release updated Oklahoma vs. Missouri predictions as Beau Pribula’s status improves

Oklahoma enters Saturday’s matchup against No. 22 Missouri with several key availability questions still hanging over the roster. Offensive guard Heath Ozaeta was added to the report as questionable on Thursday, joining a group of Sooners dealing with lingering issues, including defensive end R Mason Thomas, defensive back Gentry Williams, and running back Jovantae Barnes.

OU’s offensive line depth remains thin, with Troy Everett, Jacob Sexton, and Jake Taylor still ruled out, though the Sooners did receive good news with all four primary running backs—Xavier Robinson, Tory Blaylock, Taylor Tatum, and Jaydn Ott—remaining off the report for a second straight day.

Missouri’s injury picture shifted in a more encouraging direction, with quarterback Beau Pribula upgraded from doubtful to questionable. Pribula has been sidelined since suffering an injury in last month’s loss to Vanderbilt, forcing freshman Matt Zollers into action after he opened the season as the Tigers’ No. 3 option. With uncertainty at quarterback and both teams navigating personnel concerns, Saturday’s showdown sets up as a tightly contested SEC battle. According to Dimers’ 10,000-simulation model, Oklahoma holds a 69% chance of winning at home, with a projected final score of 26–19 and a strong lean toward the under on the 42.5-point total.

Missouri vs. Oklahoma betting preview

Utilize the interactive widget below to discover the latest spread, total, and moneyline odds and probabilities for the Missouri-Oklahoma matchup at Gaylord Family Oklahoma Memorial Stadium.

This prediction and best bet for Saturday’s college football matchup between Missouri and Oklahoma is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Missouri vs. Oklahoma matchup, including where the game is and what time it kicks off.

• Teams: Missouri vs. Oklahoma
• Date: Saturday, November 22, 2025
• Kickoff: 12 p.m. EST
• Location: Gaylord Family Oklahoma Memorial Stadium
• NCAAF rankings: Updated AP Top 25
• College football news: Check the latest updates from the official NCAA football news site

Odds

The latest and best odds for the college football matchup between the Missouri and Oklahoma.

• Spread: Missouri +6.5 (-110), Oklahoma -6.5 (-105)
• Moneyline: Missouri +200, Oklahoma -240
• Total: Over/Under 42.5 (-115/-105)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

Promos

New users in Missouri can take advantage of the FanDuel pre-launch offer ahead of December 1st.

Expert prediction: Missouri vs. Oklahoma

Using cutting-edge data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Saturday’s Missouri vs. Oklahoma matchup.

According to Dimers’ popular predictive analytics model, Oklahoma is more likely to beat Missouri at Gaylord Family Oklahoma Memorial Stadium. This prediction is based on the model giving Oklahoma a 69% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and Missouri and Oklahoma each have a 50% chance of covering the spread, while the 42.5-point over/under has a 58% chance of staying under.

These predictions and probabilities are correct at the time of publication but are subject to potential changes.

Missouri vs. Oklahoma best bet

Our top pick for the Missouri vs. Oklahoma game on Saturday is to bet on Under 42.5 points (-105).

This expert betting advice is based on world-class modeling and valuable betting intelligence, designed to help you make more informed investments.

Score prediction for Missouri vs. Oklahoma

Dimers’ predicted final score for the Missouri vs. Oklahoma game on Saturday has Oklahoma winning 26-19.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

College football Week 13: Missouri vs. Oklahoma

Get ready for Saturday’s college football matchup between Missouri and Oklahoma at Gaylord Family Oklahoma Memorial Stadium, which is scheduled to start at 12 p.m. EST. We emphasize that all of the college football predictions and college football best bets in this preview are derived from 10,000 data-driven simulations of the Missouri vs. Oklahoma matchup, and they are correct at the time of publication to help you make better decisions when placing bets at online sportsbooks.

Please note that when engaging in online betting, it is important to exercise responsible gambling practices and seek reliable sources for the latest and most accurate information.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.