Experts release early Cowboys vs. Chiefs predictions after Pickens, Gray are “DNPs” on Thanksgiving injury report

This Thanksgiving, the Kansas City Chiefs will face off against the Dallas Cowboys in a huge Week 13 matchup at AT&T Stadium. Kickoff is 4:30 p.m. EST.

After both the Chiefs and Cowboys pulled off dramatic comebacks in Week 12, each time saw a key pass catcher held out of Monday’s practice. Noah Gray was a DNP for Kansas City, while emerging superstar George Pickens did not practice for Dallas.

Following the release of the complete Chiefs vs. Cowboys injury report below, the analysts at Dimers conducted 10,000 new game simulations that accounted for the latest player availability data. The results are below, along with the complete injury reports for both Kansas City and Dallas.

Injury reports for the Chiefs vs. Cowboys on Thanksgiving Thursday:

Kansas City Chiefs

Player	Position	Injury	Mon.
Noah Gray	TE	Concussion	DNP
Trey Smith	G	Ankle	DNP
Leo Chenal	LB	Knee	LP
Rashee Rice	WR	Hamstring	LP
Xavier Worthy	WR	Ankle	LP
George Karlaftis	DE	Thumb	FP
Patrick Mahomes	QB	Groin	FP
Isiah Pacheco	RB	Knee	FP
Chris Roland-Wallace	CB	Back	FP
Jawaan Taylor	T	Knee	FP

Dallas Cowboys:

Player	Position	Injury	Mon.
Tyler Guyton	T	Ankle	DNP
Osa Odighizuwa	DT	Elbow	DNP
George Pickens	WR	Knee/Calf	DNP
KeVontae Turpin	WR	Shoulder/Illness	DNP
Jadeveon Clowney	DE	Neck	LP
Dante Fowler	DE	Shoulder	LP
Malik Hooker	S	Toe/Thigh	LP
Donovan Wilson	S	Neck	LP
DaRon Bland	CB	Wrist	FP
James Houston	DE	Wrist/Knee	FP
Hunter Luepke	FB	Hip	FP
Tyler Smith	G	Knee	FP
Solomon Thomas	DT	Calf	FP

Chiefs vs. Cowboys betting preview

This preview includes Dimers’ best bets and predicted scoreline for the Kansas City Chiefs vs. Dallas Cowboys on Thanksgiving, based on 10,000 simulations conducted immediately after the release of Monday’s injury reports.

Utilize the interactive widget below to discover the latest spread, over/under, and moneyline betting odds and probabilities for the Chiefs-Cowboys game at AT&T Stadium.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Chiefs vs. Cowboys matchup, including where the game is and what time it kicks off.

Teams: Kansas City Chiefs vs. Dallas Cowboys
Date: Thursday, November 27, 2025
Kickoff: 4:30 p.m. EST
Location: AT&T Stadium
NFL standings: Current NFL division standings
NFL injuries: Check the latest updates to the official NFL injury report

Odds

Odds for the key markets in the Chiefs-Cowboys NFL showdown.

Spread: Chiefs -5.5 (-110), Cowboys +5.5 (-110)
Moneyline: Chiefs -198, Cowboys +195
Total: Over/Under 47.5 (-110/-110)

The odds and lines featured here are the best available from selected sports betting sites at the time of publication and are subject to change. Local Chiefs fans in Missouri can unlock pre-launch sports betting deals with the Bet365 bonus code “SYRACUSE” and BetMGM bonus code ”CUSE100," while this DraftKings promo is the most popular Thanksgiving betting promo nationwide.

Expert prediction: Chiefs vs. Cowboys

Leveraging advanced data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Thursday’s Chiefs vs. Cowboys matchup.

According to Dimers’ independent predictive analytics model, the Chiefs are more likely to beat the Cowboys at AT&T Stadium. This prediction is based on the model giving the Chiefs a 68% chance of winning the game.

Furthermore, Dimers predicts that the Cowboys (+5.5) have a 54% chance of covering the spread, while the 47.5-point over/under has a 54% chance of staying under.

As always, these predictions and probabilities are accurate at the time of publication but are subject to change.

Chiefs vs. Cowboys best bet

Our top pick for the Chiefs vs. Cowboys Week 13 NFL matchup is to bet on the Cowboys +5.5 (-110).

This betting advice is based on detailed simulations and valuable betting intelligence, designed to bring you the best possible plays.

Score prediction for Chiefs vs. Cowboys

Dimers’ projected final score for the Kansas City vs. Dallas game on Thursday has the Chiefs winning 25-20.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL Week 13: Chiefs vs. Cowboys

Get ready for Thursday’s action between the Chiefs and Cowboys in Week 13 of the NFL season at AT&T Stadium, which is scheduled to start at 4:30 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this article are derived from 10,000 data-driven simulations of the Chiefs vs. Cowboys game, and they are accurate at the time of publication to help you make more informed choices when placing bets at online sportsbooks.

Please note that when engaging in online betting, it is important to exercise responsible gambling practices and consult reliable sources for accurate and up-to-date information.

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